Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives

László Juhász; Tibor Docsa; Attila Brunyászki; Pál Gergely; Sándor Antus

doi:10.1016/j.bmc.2007.03.084

Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives

Bioorg Med Chem. 2007 Jun 15;15(12):4048-56. doi: 10.1016/j.bmc.2007.03.084. Epub 2007 Apr 2.

Authors

László Juhász¹, Tibor Docsa, Attila Brunyászki, Pál Gergely, Sándor Antus

Affiliation

¹ Department of Organic Chemistry, University of Debrecen, H-4010, Debrecen, Hungary. juhaszl@delfin.unideb.hu

PMID: 17451960
DOI: 10.1016/j.bmc.2007.03.084

Abstract

Novel 5-benzyl and 5-benzylidene-thiazolidine-2,4-diones carrying 2,3-dihydrobenzo[1,4]dioxin pharmacophore were synthesized and their glycogen phosphorylase inhibitor activity was also studied.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Dioxins / chemical synthesis*
Dioxins / pharmacology*
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*
Glycogen Phosphorylase / antagonists & inhibitors*
Magnetic Resonance Spectroscopy
Mass Spectrometry

Substances

2,3-dihydrobenzo(1,4)dioxin
Dioxins
Enzyme Inhibitors
Glycogen Phosphorylase